Abstract Title:

Hesperidin opposes the negative impact of cyclophosphamide on mice kidneys.

Abstract Source:

Drug Chem Toxicol. 2019 Mar 20:1-6. Epub 2019 Mar 20. PMID: 30889984

Abstract Author(s):

Amr A Fouad, Seham A Abdel-Gaber, Manal I Abdelghany

Article Affiliation:

Amr A Fouad


The present investigation examined the prospective nephroprotective effect of hesperidin (HSN) in mice challenged with a single i.p. injection of cyclophosphamide (CPE) at a dose of 200 mg/kg. HSN (100 and 200 mg/kg/day, p.o.) was given for 10 days, starting 5 days prior to CPE administration. HSN significantly reduced the CPE-induced increments of serum creatinine and cystatin C. HSN also significantly reduced malondialdehyde, nitric oxide, Bax/Bcl-2 ratio, and caspase-3,and significantly raised total antioxidant capacity, and interleukin-10/tumor necrosis factor-α ratio in kidneys of mice received CPE. In addition, HSN significantly prevented the histopathological injury, and kidney injury molecule-1 expression in kidneys of mice given CPE. It was concluded thatHSN guarded against nephrotoxic effect of CPE in mice by tackling oxidative/nitrative stress, inflammation, and apoptosis.

Study Type : Animal Study

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