Article Publish Status: FREE
Abstract Title:

Hesperidin Attenuates Ultraviolet B-Induced Apoptosis by Mitigating Oxidative Stress in Human Keratinocytes.

Abstract Source:

Biomol Ther (Seoul). 2016 Jan 15. Epub 2016 Jan 15. PMID: 26797112

Abstract Author(s):

Susara Ruwan Kumara Madduma Hewage, Mei Jing Piao, Kyoung Ah Kang, Yea Seong Ryu, Xia Han, Min Chang Oh, Uhee Jung, In Gyu Kim, Jin Won Hyun

Article Affiliation:

Susara Ruwan Kumara Madduma Hewage


Human skin cells undergo pathophysiological processes via generation of reactive oxygen species (ROS) upon excessive exposure to ultraviolet B (UVB) radiation. This study investigated the ability of hesperidin (C28H34O15) to prevent apoptosis due to oxidative stress generated through UVB-induced ROS. Hesperidin significantly scavenged ROS generated by UVB radiation, attenuated the oxidation of cellular macromolecules, established mitochondrial membrane polarization, and prevented the release of cytochrome c into the cytosol. Hesperidin downregulated expression of caspase-9, caspase-3, and Bcl-2-associated X protein, and upregulated expression of B-cell lymphoma 2. Hesperidin absorbed wavelengths of light within the UVB range. In summary, hesperidin shielded human keratinocytes from UVB radiation-induced damage and apoptosis via its antioxidant and UVB absorption properties.

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