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Abstract Title:

High-dose vitamin C synergizes with oncolytic adenoviruses against tumor by enhancing immunogenic tumor cell death and reprogramming tumor immune microenvironment.

Abstract Source:

Mol Ther. 2021 Sep 18. Epub 2021 Sep 18. PMID: 34547462

Abstract Author(s):

Jinhu Ma, Chunxue Zhang, Gang Shi, Dan Yue, Yongheng Shu, Shichuan Hu, Zhongbing Qi, Yanwei Chen, Bin Zhang, Yong Zhang, Anliang Huang, Chao Su, Yan Zhang, Hongxin Deng, Ping Cheng

Article Affiliation:

Jinhu Ma

Abstract:

Preclinical and clinical studies have validated the antitumor effects of several oncolytic viruses (OVs). However, the efficacy of OVs is limited when they are administered as monotherapies. Combination therapy is a promising direction for oncolytic virotherapy in the future. A high dose of vitamin C (VitC) exerts anticancer effects by triggering the accretion of substantial amounts of reactive oxygen species (ROS). OVs can induce immunogenic tumor cell death and elicit an antitumor immune response. ROS play an important role in immunogenic cell death (ICD). This study aimed to explore whether high-dose VitC in combination with oncolytic adenoviruses (oAds) exhibited a synergistic antitumor effect. High-dose VitC synergized with oAds against tumor by enhancing immunogenic tumor cell death. Combination therapy with high-dose VitC and oAds significantly increased the number of T cells in the tumor microenvironment (TME) and promoted the activation of T cells. Furthermore, the antitumor effect of the combination therapy was CD8T cell dependent. In addition, combination therapy with high-dose VitC and oAds reprogramed the immunosuppressive TME. Our study provided a new strategy for combination therapy of OVs.

Study Type : In Vitro Study

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Sayer Ji
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