Complete resolution of sickle cell chronic pain with high dose vitamin D therapy: a case report and review of the literature.
J Pediatr Hematol Oncol. 2011 Oct ;33(7):549-51. PMID: 21941148
Aflac Center for Cancer and Blood Disorders Service Comprehensive Sickle Cell Program of Children's Healthcare of Atlanta, Atlanta, GA, USA. email@example.com
With age, individuals with sickle cell disease (SCD) experience daily chronic pain. Vitamin D deficiency (VDD) can result in chronic pain, osteoporosis, fractures, and muscle weakness. Several studies report a high prevalence of VDD in SCD; however, the clinical correlates have not been well described. We describe a case of SCD chronic pain associated with profound VDD, osteoporosis, and osteonecrosis. Treatment with high-dose vitamin D resulted in complete resolution of chronic pain symptoms and improvement in bone density. Randomized studies of vitamin D in SCD may help elucidate its role in the management of chronic pain and bone disease.