Abstract Title:

High doses of atorvastatin (Sortis) modify the secretory process in the exocrine portion of the pancreas.

Abstract Source:

Ann Univ Mariae Curie Sklodowska Med. 2004 ;59(2):52-6. PMID: 16146048

Abstract Author(s):

Krystyna Czerny, Jadwiga Romanowska, Ewa Kifer-Wysocka, Włodzimierz Matysiak, Teresa Masłyk

Article Affiliation:

Department and Institute of Histology and Embryology, Skubiszewski Medical University of Lublin.

Abstract:

Changes were observed in the ultrastructure of the pancreatic acinar cells in rats after administration of atorvastatin (Sortis) in the therapeutic and ten times larger dose for the period of 6 weeks. It was found that atorvastatin given to rats in the therapeutic dose (80 mg/day) stimulated the secretion in pancreocytes, whereas the ten times higher dose of atorvastatin distorts the complicated process of the release of the secretion from the cell.

Study Type : Animal Study

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