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Article Publish Status: FREE
Abstract Title:

The Role of Dietary Fiber in Rheumatoid Arthritis Patients: A Feasibility Study.

Abstract Source:

Nutrients. 2019 Oct 7 ;11(10). Epub 2019 Oct 7. PMID: 31591345

Abstract Author(s):

Julian Häger, Holger Bang, Melanie Hagen, Michael Frech, Pascal Träger, Maria V Sokolova, Ulrike Steffen, Koray Tascilar, Kerstin Sarter, Georg Schett, Jürgen Rech, Mario M Zaiss

Article Affiliation:

Julian Häger

Abstract:

Short-chain fatty acids are microbial metabolites that have been shown to be key regulators of the gut-joint axis in animal models. In humans, microbial dysbiosis was observed in rheumatoid arthritis (RA) patients as well as in those at-risk to develop RA, and is thought to be an environmental trigger for the development of clinical disease. At the same time, diet has a proven impact on maintaining intestinal microbial homeostasis. Given this association, we performed a feasibility study in RA patients using high-fiber dietary supplementation with the objective to restore microbial homeostasis and promote the secretion of beneficial immunomodulatory microbial metabolites. RA patients (= 36) under routine care received daily high-fiber bars or cereals for 28 days. Clinical assessments and laboratory analysis of immune parameters in blood and stool samples from RA patients were done before and after the high-fiber dietary supplementation. We observed an increase in circulating regulatory T cell numbers, favorable Th1/Th17 ratios, as well as decreased markers of bone erosion in RA patients after 28 days of dietary intervention. Furthermore, patient-related outcomes of RA improved. Based on these results, we conclude that controlled clinical studies of high-fiber dietary interventions could be a viable approach to supplement or complement current pharmacological treatment strategies.

Study Type : Human Study
Additional Links
Pharmacological Actions : Immunomodulatory : CK(2249) : AC(733)
Additional Keywords : Gut-joint axis

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