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Abstract Title:

High-fructose corn syrup enhances intestinal tumor growth in mice.

Abstract Source:

Science. 2019 03 22 ;363(6433):1345-1349. PMID: 30898933

Abstract Author(s):

Marcus D Goncalves, Changyuan Lu, Jordan Tutnauer, Travis E Hartman, Seo-Kyoung Hwang, Charles J Murphy, Chantal Pauli, Roxanne Morris, Sam Taylor, Kaitlyn Bosch, Sukjin Yang, Yumei Wang, Justin Van Riper, H Carl Lekaye, Jatin Roper, Young Kim, Qiuying Chen, Steven S Gross, Kyu Y Rhee, Lewis C Cantley, Jihye Yun

Article Affiliation:

Marcus D Goncalves

Abstract:

Excessive consumption of beverages sweetened with high-fructose corn syrup (HFCS) is associated with obesity and with an increased risk of colorectal cancer. Whether HFCS contributes directly to tumorigenesis is unclear. We investigated the effects of daily oral administration of HFCS in adenomatous polyposis coli (APC) mutant mice, which are predisposed to develop intestinal tumors. The HFCS-treated mice showed a substantial increase in tumor size and tumor grade in the absence of obesity and metabolic syndrome. HFCS increased the concentrations of fructose and glucose in the intestinal lumen and serum, respectively, and the tumors transported both sugars. Within the tumors, fructose was converted to fructose-1-phosphate, leading to activation of glycolysis and increased synthesis of fatty acids that support tumor growth. These mouse studies support the hypothesis that the combination of dietary glucose and fructose, even at a moderate dose, can enhance tumorigenesis.

Study Type : Animal Study
Additional Links
Adverse Pharmacological Actions : Tumorigenic : CK(16) : AC(11)

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