Article Publish Status: FREE
Abstract Title:

Neonatal Vitamin D Status and Risk of Asthma in Childhood: Results from the D-Tect Study.

Abstract Source:

Nutrients. 2020 Mar 21 ;12(3). Epub 2020 Mar 21. PMID: 32245170

Abstract Author(s):

Fanney Thorsteinsdottir, Isabel Cardoso, Amélie Keller, Maria Stougaard, Peder Frederiksen, Arieh Sierra Cohen, Ekaterina Maslova, Ramune Jacobsen, Vibeke Backer, Berit Lilienthal Heitmann

Article Affiliation:

Fanney Thorsteinsdottir


BACKGROUND: low vitamin D status in pregnancy can influence the offspring's lung function and contribute to childhood asthma development. The objective of this study was to examine the influence of neonatal vitamin D status on the development of asthma among children age 3-9 years in a large population sample.

METHOD: in a case-cohort study utilizing a Danish biobank and register data we examined the association between neonatal 25-hydroxyvitamin D(25(OH)D) concentrations and incidence of asthma among children aged 3-9 years. Cases of asthma (= 911) were randomly selected among all cases of asthma in the Danish National Patient Register from children born between 1992 and 2002. The sub-cohort (= 1423) was randomly selected among all children born in the same period. We used a weighted Cox proportional hazard model assessing the hazard of first asthma diagnoses by quintiles of 25(OH)D.

RESULTS: the median 25(OH)D3 (interquartile range) for asthma cases was 23 nmol/L (14-35) and the sub-cohort 25 nmol/L (14-40). The hazard ratio for developing asthma between ages 3 and 9 years was lower for children in the fifth quintile of neonatal 25(OH)Dcompared to children in the first quintile, both in the unadjusted (0.61 95% CI: 0.46-0.80) and adjusted (0.55 95% CI: 0.39-0.77) analyses.

CONCLUSION: the results from our study suggest that higher neonatal vitamin D concentration may reduce the risk of developing childhood asthma at ages 3-9 years, indicating that neonatal vitamin D status as a proxy of vitamin D status during the prenatal period is important for normal immune- and lung development.

Study Type : Human Study
Additional Links
Pharmacological Actions : Anti-Asthmatic Agents : CK(24) : AC(3)

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Sayer Ji
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