Abstract Title:

Histidine and carnosine delay diabetic deterioration in mice and protect human low density lipoprotein against oxidation and glycation.

Abstract Source:

Cont Lens Anterior Eye. 2008 Jun;31(3):141-6; quiz 170. Epub 2008 Mar 4. PMID: 15878720

Abstract Author(s):

Yuan-ti Lee, Cheng-chin Hsu, Meng-hsiao Lin, Keh-sen Liu, Mei-chin Yin

Article Affiliation:

Department of Internal Medicine, Chungshan Medical University Hospital, Taichung City, Taiwan, ROC.


In vivo effects of histidine and carnosine against diabetic deterioration in diabetic Balb/cA mice were studied. Histidine and carnosine at 0.5, 1 g/l were added into drinking water. After 4 weeks intake of these agents, the content of histidine and carnosine in plasma, heart and liver significantly elevated (P<0.05). The intake of these agents significantly decreased plasma glucose and fibronectin levels (P<0.05); however, only 1 g/l histidine and carnosine treatments significantly increased insulin level (P<0.05) in diabetic mice. Triglyceride level in heart and liver was dose-dependently reduced by histidine or carnosine treatments (P<0.05); however, only 1 g/l histidine and carnosine treatments significantly reduced cholesterol level in heart and liver (P<0.05). The administration of histidine or carnosine significantly enhanced catalase activity and decreased lipid oxidation levels in kidney and liver (P<0.05); however, only 1 g/l histidine and carnosine treatments significantly increased glutathione peroxidase activity (P<0.05). The increased interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha in diabetic mice were significantly suppressed by the intake of histidine or carnosine (P<0.05). In human low density lipoprotein, histidine or carnosine showed dose-dependently suppressive effect in glucose-induced oxidation and glycation (P<0.05). These data suggest that histidine and carnosine are potential multiple-protective agents for diabetic complications prevention or therapy.

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