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Abstract Title:

Honokiol inhibits hepatoma carcinoma cell migration through downregulated Cyclophilin B expression.

Abstract Source:

Biochem Biophys Res Commun. 2021 May 7 ;552:44-51. Epub 2021 Mar 17. PMID: 33743348

Abstract Author(s):

Young-Seok Lee, Suyun Jeong, Ki-Yoon Kim, Ji-Su Yoon, Sungsoo Kim, Kyung-Sik Yoon, Joohun Ha, Insug Kang, Wonchae Choe

Article Affiliation:

Young-Seok Lee

Abstract:

Hepatocellular carcinoma (HCC) is the fifth common types of cancer with poor prognosis in the world. Honokiol (HNK), a natural biphenyl compound derived from the magnolia plant, has been reported to exert anticancer effects, but its mechanism has not been elucidated exactly. In the present study, HNK treatment significantly suppressed the migration ability of HepG2 and Hep3B human hepatocellular carcinoma. The treatment reduced the expression levels of the genes associated with cell migration, such as S100A4, MMP-2, MMP-9 and Vimentin. Interestingly, treatment with HNK significantly reduced the expression level of Cyclophilin B (CypB) which stimulates cancer cell migration. However, overexpressed CypB abolished HNK-mediated suppression of cell migration, and reversed the apoptotic effects of HNK. Altogether, we concluded that the suppression of migration activities by HNK was through down-regulated CypB in HCC. These finding suggest that HNK may be a promising candidate for HCC treatment via regulation of CypB.

Study Type : In Vitro Study

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Sayer Ji
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