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Abstract Title:

Serum 25-hydroxyvitamin D levels in hospitalized adults with community-acquired pneumonia.

Abstract Source:

Clin Respir J. 2018 Jul ;12(7):2220-2227. Epub 2018 Apr 16. PMID: 29570946

Abstract Author(s):

María L Brance, Julio N Miljevic, Raquel Tizziani, María E Taberna, Georgina P Grossi, Pablo Toni, Elina Valentini, Andrea Trepat, Julia Zaccardi, Juan Moro, Baltasar Finuci Curi, Norberto Tamagnone, Mariano Ramirez, Javier Severini, Pablo Chiarotti, Francisco Consiglio, Raúl Piñeski, Albertina Ghelfi, Jorge Kilstein, Eduardo Street, Dino Moretti, Viviana Oliveto, Marcelo Mariño, Jorge Manera, Lucas R Brun

Article Affiliation:

María L Brance

Abstract:

INTRODUCTION: Community-acquired pneumonia (CAP) is the infectious disease with the highest number of deaths worldwide. Several studies have shown an association between vitamin D deficiency and increases susceptibility to respiratory tract infections.

OBJECTIVE: The aim of this study was to evaluate the serum 25-hydroxyvitamin D (25OHD) levels in hospitalized adults in general room with CAP.

MATERIALS AND METHODS: An observational study was carried out in 207 hospitalized adults of both sex with CAP (>18 years) from Rosario city, Argentina (32° 52' 18″S) between July 2015 and June 2016.

RESULTS: In total, 167 patients were included in the data analysis [59% women (57.4 ± 19.6 years), body mass index 27.2 ± 7.8 kg/m]. In brief, 63% showed unilobar infiltrate and 37% were multilobar. The CURB-65 index was 66.5% low risk, 16.0% intermediate risk and 17.5% high risk. According to Charlson comorbidity index (CCI) 53.5% had not comorbidity (CCI = 0) and 46.5% showed CCI ≥ 1. The 25OHD level was: 11.92 ± 7.6 ng/mL (51.5%:<10 ng/mL, 33.5%: 10-20 ng/mL, 13.2%: 20-30 ng/mL and 1.8%:>30 ng/mL). Higher 25OHD were found in male (female: 10.8 ± 6.7 ng/mL, male: 13.5 ± 8.5 ng/mL, P = .02) and 25OHD correlated with age (r = -.17; P = .02). 25-Hydroxyvitamin D was also correlated with CURB65 index (r = -.13; P = .049), CCI (r = -.20, P = .007) and with the 10 years of life expectative (%) (r = .19;P = .008). In addition, higher 25OHD were found with lower CCI (CCI 0 = 13.0 ± 8.2 ng/mL, CCI ≥ 1= 10.5 ± 6.7 ng/mL; P = .0093).

CONCLUSIONS: Hospitalized adults with CAP have lower 25OHD levels and would be associated with the severity of CAP.

Study Type : Human Study

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