Incidence and onset of delayed seizures after overdoses of extended-release bupropion.
Am J Emerg Med. 2009 Oct ;27(8):911-5. PMID: 19857406
Maryland Poison Center/Department of Pharmacy Practice and Science, University of Maryland Baltimore, Baltimore, MD 21201, USA. email@example.com
BACKGROUND: Delayed seizures have been reported with overdoses of bupropion extended-release (XL). This study systematically evaluates the frequency and timing of seizures and an association between other toxic effects (ie, agitation, tremors, and hallucinations) and seizures.
METHODS: A 3-year multi-poison center observational study of hospitalized patients with ingestion of bupropion XL>or=600 mg in adults and>or=4 mg/kg in children was performed. Patients with coingestants or a medical history that could affect seizure occurrence were excluded. Data collection forms captured onset time of seizure(s), other symptoms, and treatment.
RESULTS: One hundred seventeen patients met inclusion criteria: median age of 22 years (range, 1.3-65 years) with 16 children
CONCLUSION: Delayed seizure onset suggests a minimum observation period of 24 hours after bupropion XL overdose. Although patients experiencing agitation or tremors may be at greater risk, seizures can occur without preceding central nervous system toxicity.