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Abstract Title:

Huperzine A: A promising anticonvulsant, disease modifying, and memory enhancing treatment option in Alzheimer's disease.

Abstract Source:

Med Hypotheses. 2017 Feb ;99:57-62. Epub 2016 Dec 22. PMID: 28110700

Abstract Author(s):

Ugur Damar, Roman Gersner, Joshua T Johnstone, Steven Schachter, Alexander Rotenberg

Article Affiliation:

Ugur Damar

Abstract:

Alzheimer's disease (AD) is the most frequent cause of dementia. Besides cognitive deterioration, patients with AD are prone to seizures - more than 20% of patients diagnosed with AD experience at least one unprovoked seizure and up to 7% have recurrent seizures. Although available antiepileptic drugs (AEDs) may suppress seizures in patients with AD, they may also worsen cognitive dysfunction and increase the risk of falls. On the basis of preclinical studies, we hypothesize that Huperzine A (HupA), a safe and potent acetylcholinesterase (AChE) inhibitor with potentially disease-modifying qualities in AD, may have a realistic role as an anticonvulsant in AD.

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Sayer Ji
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