n/a
Article Publish Status: FREE
Abstract Title:

Red Propolis and Its Dyslipidemic Regulator Formononetin: Evaluation of Antioxidant Activity and Gastroprotective Effects in Rat Model of Gastric Ulcer.

Abstract Source:

Nutrients. 2020 Sep 26 ;12(10). Epub 2020 Sep 26. PMID: 32993069

Abstract Author(s):

Marcio A A de Mendonça, Ana R S Ribeiro, Adriana K de Lima, Gislaine B Bezerra, Malone S Pinheiro, Ricardo L C de Albuquerque-Júnior, Margarete Z Gomes, Francine F Padilha, Sara M Thomazzi, Ettore Novellino, Antonello Santini, Patricia Severino, Eliana B Souto, Juliana C Cardoso

Article Affiliation:

Marcio A A de Mendonça

Abstract:

Propolis has various pharmacological properties of clinical interest, and is also considered a functional food. In particular, hydroalcoholic extracts of red propolis (HERP), together with its isoflavonoid formononetin, have recognized antioxidant and anti-inflammatory properties, with known added value against dyslipidemia. In this study, we report the gastroprotective effects of HERP (50-500 mg/kg, p.o.) and formononetin (10 mg/kg, p.o.) in ethanol and non-steroidal anti-inflammatory drug-induced models of rat ulcer. The volume, pH, and total acidity were the evaluated gastric secretion parameters using the pylorus ligature model, together with the assessment of gastric mucus contents. The anti-activities of HERP were evaluated using the agar-well diffusion method. In our experiments, HERP (250 and 500 mg/kg) and formononetin (10 mg/kg) reduced (<0.001) total lesion areas in the ethanol-induced rat ulcer model, and reduced (<0.05) ulcer indices in the indomethacin-induced rat ulcer model. Administration of HERP and formononetin to pylorus ligature models significantly decreased (<0.01) gastric secretion volumes and increased (<0.05) mucus production. We have also shown the antioxidant and anti-activities of HERP. The obtained results indicate that HERP and formononetin are gastroprotective in acute ulcer models, suggesting a prominent role of formononetin in the effects of HERP.

Print Options


Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.