n/a
Article Publish Status: FREE
Abstract Title:

Hydrocortisone, Vitamin C and thiamine for the treatment of sepsis and septic shock following cardiac surgery.

Abstract Source:

Indian J Anaesth. 2018 Dec ;62(12):934-939. PMID: 30636793

Abstract Author(s):

Mahesh Balakrishnan, Hemang Gandhi, Komal Shah, Himani Pandya, Ramesh Patel, Sunny Keshwani, Nikhil Yadav

Article Affiliation:

Mahesh Balakrishnan

Abstract:

Background and Aims: The effect of vitamin C on vasopressor requirement in critically ill patients have been evaluated previously. We aimed to evaluate the effect of vitamin C, hydrocortisone and thiamine on vasopressor requirement and mortality in post-operative adult cardiac surgical patients with septic shock.

Methods: About 24 patients with septic shock were randomised into Group 1 (receiving matching placebo per day for 4 days) and Group 2 (receiving 6 g vitamin C, 400 mg thiamine and 200 mg hydrocortisone per day for 4 days). Vasopressor dose over 4 days of therapy was the primary endpoint, whereas in-hospital mortality was the secondary endpoint.

Results: APACHE IV and EUROSCORE II scores were similar between both the groups. Significant reductions in the requirement of vasopressin (difference from day 1 - 0.0008± 0.00289 vs 0.0033 ± 0.00492 units/kg/min;= 0.019) and noradrenaline (difference from day 1 - 0.0283± 0.040 vs 0.023 ± 0.035 μg/kg/min;= 0.006) were observed with vitamin C treatment as compared to control group. PCT levels on Day 3 (68.11± 33.64 vs 33.2 ± 27.55 ng/mL;= 0.0161) and Day 4 (70.03± 29.74 vs 26.3 ± 23.08 ng/mL;= 0.0009) were significantly lower in treatment group as compared to control. However, there was no difference in the Sepsis-Related Organ Failure Assessment (SOFA) score and mortality between the studied groups.

Conclusion: Combination of vitamin C, thiamine and hydrocortisone reduces vasopressor requirement in adult cardiac surgical patients with septic shock.

Study Type : Human Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.