Abstract Title:

Effects of hyperbaric oxygen on proliferation and differentiation of osteoblasts from human alveolar bone.

Abstract Source:

Langenbecks Arch Surg. 2011 Apr 14. Epub 2011 Apr 14. PMID: 17653977

Abstract Author(s):

Dong Wu, Jos Malda, Ross Crawford, Yin Xiao

Abstract:

In view of the controversy of the clinical use of hyperbaric oxygen (HBO) treatment to stimulate fracture healing and bone regeneration, we have analyzed the effects of daily exposure to HBO on the proliferation and differentiation of human osteoblasts in vitro. HBO stimulated proliferation when osteoblasts were cultured in 10% fetal calf serum (FCS), whereas an inhibitory effect of HBO was observed when cultures were supplemented with 2% FCS. On the other hand, HBO enhanced biomineralization with an increase in bone nodule formation, calcium deposition, and alkaline phosphatase activity, whereas no cytotoxic effect was detected using a lactate dehydrogenase activity assay. The data suggest that the exposure of osteoblasts to HBO enhances differentiation toward the osteogenic phenotype, providing cellular evidence of the potential application of HBO in fracture healing and bone regeneration.

Study Type : In Vitro Study
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