Hyperglycemia is associated with psoriatic inflammation in both humans and mice. - GreenMedInfo Summary
Hyperglycemia is associated with psoriatic inflammation in both humans and mice.
J Invest Dermatol. 2019 Feb 15. Epub 2019 Feb 15. PMID: 30776434
Chronic low-grade inflammation can cause several metabolic syndromes. Patients with psoriasis, a chronic immunological skin inflammation, often develop diabetes. However, it is not clear to date how psoriasis leads to, or is correlated with, glucose intolerance. Here, we investigate whether psoriasis itself correlates with hyperglycemia in humans and mice. In patients, severity of psoriasis was correlated with high blood glucose levels and treatment of psoriasis by phototherapy improved insulin secretion. Imiquimod (IMQ)-induced systemic and cutaneous inflammation in mice, with features of human psoriasis, also resulted in hyperglycemia. Although it should be determined if psoriasis-like cutaneous inflammation alone can induce hyperglycemia, IMQ-treated mice showed impairment of insulin secretion without significant islet inflammation. Notably, administration of anti-IL-17A mAb improved hyperglycemia in psoriatic patients and IMQ-treated mice with psoriasiform features. These results suggest that hyperglycemia is highly associated with psoriasis, mainly through IL-17.