Abstract Title:

Icariin, a natural flavonol glycoside, induces apoptosis in human hepatoma SMMC-7721 cells via a ROS/JNK-dependent mitochondrial pathway.

Abstract Source:

Cancer Lett. 2010 Dec 8 ;298(2):222-30. Epub 2010 Jul 31. PMID: 20674153

Abstract Author(s):

Songgang Li, Ping Dong, Jianwei Wang, Jie Zhang, Jun Gu, Xiangsong Wu, Wenguang Wu, Xiaozhou Fei, Zhiping Zhang, Yong Wang, Zhiwei Quan, Yingbin Liu

Article Affiliation:

Department of General Surgery, Xinhua Hospital, Shanghai Jiao Tong University, Shanghai, China.

Abstract:

In this study, the anticancer effect of icariin, a natural flavonol glycoside, against human hepatoma SMMC-7721 cells and the underlying mechanisms were investigated. Icariin triggered the mitochondrial/caspase apoptotic pathway indicated by enhanced Bax-to-Bcl-2 ratio, loss of mitochondrial membrane potential, cytochrome c release, and caspase cascade. Moreover, icariin induced a sustained activation of the phosphorylation of c-Jun N-terminal kinase (JNK) but not p38 and ERK1/2, and SP600125 (an inhibitor of JNK) almost reversed icariin-induced apoptosis in SMMC-7721 cells. In addition, icariin provoked the generation of reactive oxygen species (ROS) in SMMC-7721 cells, while the antioxidant N-acetyl cysteine almost completely blocked icariin-induced JNK activation and apoptosis. Taken together, these findings suggest that icariin induces apoptosis through a ROS/JNK-dependent mitochondrial pathway.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Apoptotic : CK(6986) : AC(5304)

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