Article Publish Status: FREE
Abstract Title:

Identification of Anti-Inflammatory Compounds from Hawaiian Noni (L.) Fruit Juice.

Abstract Source:

Molecules. 2020 Oct 27 ;25(21). Epub 2020 Oct 27. PMID: 33121016

Abstract Author(s):

Dahae Lee, Jae Sik Yu, Peng Huang, Mallique Qader, Arulmani Manavalan, Xiaohua Wu, Jin-Chul Kim, Changhyun Pang, Shugeng Cao, Ki Sung Kang, Ki Hyun Kim

Article Affiliation:

Dahae Lee


Noni (L.) fruit juice has been used in Polynesia as a traditional folk medicine and is very popular worldwide as a functional food supplement. In this study, compounds present in Hawaiian Noni fruit juice, with anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells were identified. Five compounds were isolated using a bioassay-driven technique and phytochemical analysis of noni fruit juice: asperulosidic acid (), rutin (), nonioside A (), (2,4,7)-deca-2,4,7-trienoate-2--β-d-glucopyranosyl-β-d-glucopyranoside (), and tricetin (). The structures of these five compounds were determined via NMR spectroscopy and LC/MS. In an anti-inflammatory assay, compounds-inhibited the production of nitric oxide (NO), which is a proinflammatory mediator, in LPS-stimulated macrophages. Moreover, the mechanisms underlying the anti-inflammatory effects of compounds-were investigated. Parallel to the inhibition of NO production, treatment with compounds-downregulated the expression of IKKα/β, I-κBα, and NF-κB p65 in LPS-stimulated macrophages. Furthermore, treatment with compounds-downregulated the expression of nitric oxide synthase and cyclooxygenase-2. Thus, these data demonstrated that compounds-present in noni fruit juice, exhibited potential anti-inflammatory activity; these active compounds may contribute preventively and therapeutically against inflammatory diseases.

Study Type : In Vitro Study

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