Immune-enhancing effects of200655 isolated from Korean kimchi in a cyclophosphamide-induced immunocompromised mouse model.
J Microbiol Biotechnol. 2021 Apr 5. Epub 2021 Apr 5. PMID: 33820888
Kyeong Jin Kim
This study aimed to evaluate the immune-enhancing activity of200655-derived from kimchi on immune suppression by cyclophosphamide (CP) in ICR mice. Animals were fed distilled water or 1×10colony-forming unit/kg B.W. 200655 orGG as a positive control for 14 days. An in vivo model of immunosuppression was induced using CP 150 and 100 mg/kg BW at 7 and 10 days, respectively. The body weight, spleen index, spleen weight, and gene expression were measured to estimate immune-enhancing effects. The dead 200655 (D-200655) group showed an increased spleen weight compared to the sham control group. Similarly, the spleen index was significantly higher than that in the CP-treated group. The Live 200655 (L-200655) group showed an increased mRNA expression of tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-6 in splenocytes. Also, the iNOS and COX-2 mRNA expression was upregulated in L-200655 group compared to SC group. The phosphorylation of ERK and MAPK was also upmodulated in L-200655 group. These results indicate that200655 ameliorated CP-induced immune suppression, suggesting that200655 may have the potential to enhance the immune system.