Immune modulation of shikonin in a rat allergic rhinitis model - GreenMedInfo Summary
[Immune modulation of shikonin in a rat allergic rhinitis model].
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Oct 20 ;30(20):1626-1629. PMID: 29871159
To study intervention effect of shikonin on immune function of dendritic cells using a rat allergic rhinitis model.Forty rats were divided into three groups include OVA group(n=15),OVA+ shikonin group(n=15), and control group(n=10).The rat allergic rhinitis model was estabilshed after OVA sensitization and local challenge. 100μg/ml shikonin was spray inhalated after OVA challenge in OVA+ shikonin group. The expression of CD80,CD86,IL-10 and IL-12 was deteced by immunohistochemistry in three groups.In OVA+ shikonin group, the CD80 value was 13.52± 3.53,CD86 value was 24.01±13.12;in OVA group, the CD80 value was 17.19± 4.42 and the CD86 value was 38.89±9.77.The IL-10 value was 6.69±1.12 and 3.61± 0.23 in OVA group and OVA+ shikonin group,respectively.The IL-12 value was 44.30± 9.70 and 28.80+8.20 in OVA group and OVA+ shikonin group,respectively.The shikonin has effect on immune modulation in rat model of allergic rhinitis.