Immune-stimulating Effect ofLn1 Isolated from the Traditional Korean Fermented Food, Kimchi.
J Microbiol Biotechnol. 2020 Mar 20. Epub 2020 Mar 20. PMID: 32238764
Hye Ji Jang
This study aimed to determine the immune-stimulating effects of heat-killedLn1 (HK-Ln1) through the production of nitric oxide (NO) and pro-inflammatory cytokine achieved by inducing NF-κB and mitogen-activated protein kinase (MAPK)-signaling pathways in macrophages. HK-Ln1 showed higher NO and cytokine production compared to control (non-stimulated lipopolysaccharide); in addition, the expression of inducible nitric oxide synthase (iNOS) was induced through HK-Ln1treatment. The phosphorylation of IκB-α and p65 increased following treatment by HK-Ln1, which implicates IκB-α degradation and the translocation of p65 to nucleus. In addition, the phosphorylation of MAPKs, ERK 1/2, JNK, and p38 was induced following HK-Ln1 treatment.