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Article Publish Status: FREE
Abstract Title:

Immunomodulatory Effect of Flavonoids of Blueberry (L.) Leaves via the NF-B Signal Pathway in LPS-Stimulated RAW 264.7 Cells.

Abstract Source:

J Immunol Res. 2017 ;2017:5476903. Epub 2017 Dec 27. PMID: 29445755

Abstract Author(s):

Dazhi Shi, Mengyi Xu, Mengyue Ren, Enshan Pan, Chaohua Luo, Wei Zhang, Qingfa Tang

Article Affiliation:

Dazhi Shi

Abstract:

Objective: This study aimed to explore the immunoregulatory effect of flavonoids of blueberry (L.) leaves (FBL).

Methods: The flavonoids of blueberry leaves were prepared with 70% ethanol and were identified by ultraperformance liquid chromatography/quadrupole-time-of-flight mass spectrometry (UPLC/Q-Tof-MS). The immunoregulatory effect and possible regulatory mechanisms of FBL were investigated in lipopolysaccharide- (LPS-) induced RAW 264.7 cells.

Results: According to the results of UPLC/Q-Tof-MS, nine flavonoids of blueberry leaves were identified. FBL showed a significant reduction in the production of TNF-in LPS-stimulated RAW 264.7 cells. FBL significantly decreased the expression of NF-B p65 and P-NF-B p65 in LPS-induced RAW 264.7 cells in a dose-dependent manner.

Conclusion: Our study showed the immunoregulatory effect of FBL through the suppression of TNF-via the NF-B signal pathway.

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