Immunomodulatory effects of Lactobacillus plantarum on inflammatory response induced by Klebsiella pneumoniae.
Infect Immun. 2019 Sep 3. Epub 2019 Sep 3. PMID: 31481408
Some respiratory infections have been associated with dysbiosis of the intestinal microbiota. The underlying mechanism is incompletely understood but crosstalk between intestinal microbiota and local immune cells could influence the immune response at distal mucosal sites. This has led to the concept of enhancing respiratory defences by modulating the intestinal microbiota with exogenous supplementation of beneficial strains. In this study, we examined the effect ofon the inflammatory response induced by the pathogenOral administration ofto mice subsequently infected byvia the nasal route i) reduced the pulmonary inflammation response, with decreased numbers of lung innate immune cells (macrophages, and neutrophils) and cytokines (KC, IL-6 and TNF-α) in the bronchoalveolar fluid and ii) induced an immunosuppressive Treg response in lungs.co-incubation ofandwith human dendritic cells and peripheral blood mononuclear cells resulted in decreased Th1 (IL-12p70; IFN-γ) and Th17 (IL-23, IL-17) and increased Treg (IL-10) cytokine levels compared to those observed with-infected cells. Neithernorhad any effect on cytokine production by intestinal epithelial cells, but the induction of NF-κB pathway and IL-8 and IL-6 production byin airway epithelial cells was significantly reduced when the pathogen was co-incubated withThe remote IL-10-mediated modulation ofinflammatory response bysupports the concept of immunomodulation by beneficial bacteria through the gut-lung axis.