The impact of some natural phenolic compounds on carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, andα-glycosidase enzymes: An antidiabetic, anticholinergic, and antiepileptic study.
J Biochem Mol Toxicol. 2017 Dec ;31(12). Epub 2017 Sep 13. PMID: 28902458
Natural products from food and plant sources have been used for medicinal usage for ages. Also, natural products with therapeutic significance are compounds derived from animals, plants, or any microorganism. In this study, chrysin, carvacrol, hesperidin, zingerone, and naringin as natural phenols showed excellent inhibitory effects against human (h) carbonic anhydrase (CA) isoforms I and II (hCA I and II),α-glucosidase (α-Gly), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). These phenolic compounds were tested for the inhibition of α-glycosidase, hCA I, hCA II, AChE, and BChE enzymes and demonstrated efficient inhibition profiles with Kvalues in the range of 3.70 ± 0.92-79.66 ± 20.81 nM against hCA I, 2.98 ± 0.33-84.88 ± 40.32 nM against hCA II, 4.93 ± 2.01-593.60 ± 134.74 nM against α-Gly, 0.52 ± 0.18-46.80 ± 17.15 nM against AChE, and 1.25 ± 0.22-32.08 ± 2.68 against BChE.