Improvement of testosterone deficiency by fermentedextracts in aging male rats.
Food Sci Biotechnol. 2021 Mar ;30(3):443-454. Epub 2021 Feb 6. PMID: 33868755
Kyeong Soo Lee
: This study evaluated the efficacy of(MC; bitter melon) extracts against andropause symptoms. We fermented MC withand verified the ability of the fermented MC extracts (FMEs) to control testosterone deficiency by using aging male rats as an animal model of andropause. FME administration considerably increased total and free testosterone levels, muscle mass, forced swimming time, and total and motile sperm counts in aging male rats. In contrast, sex hormone-binding globulin, retroperitoneal fat, serum cholesterol, and triglyceride levels were significantly reduced in the treated groups compared to the non-treated control aging male rats. Furthermore, we observed that FME enhanced the expression of testosterone biosynthesis-related genes but reduced the expression of testosterone degradation-related genes in a mouse Leydig cell line. These results suggest that FME has effective pharmacological activities that increase and restore free testosterone levels and that FME may be employed as a promising natural product for alleviating testosterone deficiency syndrome.
Supplementary Information: The online version contains supplementary material available at 10.1007/s10068-020-00872-x.