[The incidence of latent asymptomatic celiac disease in women with decreased fertility].
Ceska Gynekol. 2013 ;78(3):247-51. PMID: 23869830
Objective: To determine whether patients with recurrent spontaneous abortions and IVF suffer from latent celiac disease.Design: Perspective study.Settings: Department of Gynecology and Obstetrics and Faculty Hospital, Charles University, Pilsen.Material and methods: Sera from 442 infertile patients aged 23-47 years and 86 healthy fertile controls aged 22-38 years were examined by commercial ELISA sets for the presence (absence) of antibodies against gliadin IgG, IgA and tissue transglutaminase in IgG and IgA. Results: We found a statistically significant difference between the control group and patients with decreased fertility. They have a positive values in anti-tissue transglutaminase IgA (p = 0.0096). Frequent, very low positive reaction of antigliadin IgG was also found in the control group of women.Conclusion: Patients with unexplained repeated miscarriages and repeated unsuccessful IVF with IgA positive tissue transglutaminase have new complement of other tests for autoimmunity and examination of a total IgA, and gastroenterological examination. Eleven patients with significant positive anti-tissue transglutaminase IgA were successfully conceived only under strict gluten-free diet. Keywords: infertility - celiac disease - antibodies - gliadin - tissue transglutaminase.