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Abstract Title:

Bisphenol A exposure and asthma development in school-age children: a longitudinal study.

Abstract Source:

PLoS One. 2014 ;9(10):e111383. Epub 2014 Oct 30. PMID: 25356742

Abstract Author(s):

Kyoung-Nam Kim, Jin Hee Kim, Ho-Jang Kwon, Soo-Jong Hong, Byoung-Ju Kim, So-Yeon Lee, Yun-Chul Hong, Sanghyuk Bae

Article Affiliation:

Kyoung-Nam Kim


BACKGROUND: Although the effect of bisphenol A on various health outcomes has been extensively examined, few studies have investigated its effect on asthma.

OBJECTIVE: We hypothesized that exposure to bisphenol A in school-age children was associated with wheezing and asthma.

METHODS: Participants included 127 children aged 7-8 years without a previous asthma diagnosis in an elementary school in Seoul, Korea. Three surveys were conducted, each 2 years apart. Bisphenol A concentration was measured at the baseline survey, and PC20, which is defined as the methacholine concentration that induces a decrease in FEV1 of 20% from baseline, was measured at every survey. Associations between bisphenol A concentration at 7-8 years of age and wheezing, asthma, and PC20 at ages up to 11-12 years were examined using generalized estimating equations, a marginal Cox regression model, and a linear mixed model.

RESULTS: The log-transformed creatinine-adjusted urinary bisphenol A concentration at 7-8 years was positively associated with wheezing (odds ratio, 2.48; 95% confidence interval, 1.15-5.31; P = .02) and asthma (hazard ratio, 2.13; 95% confidence interval, 1.51-3.00; P<.001) at ages up to 11-12 years. Bisphenol A was also negatively associated with PC20 (ß = -2.33; P = .02). When stratified by sex, the association between bisphenol A and asthma remained significant only in girls (hazard ratio, 2.45; 95% confidence interval, 2.18-2.76; P<.001).

CONCLUSION: Increased urinary bisphenol A concentrations at 7-8 years old were positively associated with wheezing and asthma and negatively associated with PC20 at ages up to 11-12 years.

Study Type : Human Study

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