n/a
Article Publish Status: FREE
Abstract Title:

Bisphenol A exposure and asthma development in school-age children: a longitudinal study.

Abstract Source:

PLoS One. 2014 ;9(10):e111383. Epub 2014 Oct 30. PMID: 25356742

Abstract Author(s):

Kyoung-Nam Kim, Jin Hee Kim, Ho-Jang Kwon, Soo-Jong Hong, Byoung-Ju Kim, So-Yeon Lee, Yun-Chul Hong, Sanghyuk Bae

Article Affiliation:

Kyoung-Nam Kim

Abstract:

BACKGROUND: Although the effect of bisphenol A on various health outcomes has been extensively examined, few studies have investigated its effect on asthma.

OBJECTIVE: We hypothesized that exposure to bisphenol A in school-age children was associated with wheezing and asthma.

METHODS: Participants included 127 children aged 7-8 years without a previous asthma diagnosis in an elementary school in Seoul, Korea. Three surveys were conducted, each 2 years apart. Bisphenol A concentration was measured at the baseline survey, and PC20, which is defined as the methacholine concentration that induces a decrease in FEV1 of 20% from baseline, was measured at every survey. Associations between bisphenol A concentration at 7-8 years of age and wheezing, asthma, and PC20 at ages up to 11-12 years were examined using generalized estimating equations, a marginal Cox regression model, and a linear mixed model.

RESULTS: The log-transformed creatinine-adjusted urinary bisphenol A concentration at 7-8 years was positively associated with wheezing (odds ratio, 2.48; 95% confidence interval, 1.15-5.31; P = .02) and asthma (hazard ratio, 2.13; 95% confidence interval, 1.51-3.00; P<.001) at ages up to 11-12 years. Bisphenol A was also negatively associated with PC20 (ß = -2.33; P = .02). When stratified by sex, the association between bisphenol A and asthma remained significant only in girls (hazard ratio, 2.45; 95% confidence interval, 2.18-2.76; P<.001).

CONCLUSION: Increased urinary bisphenol A concentrations at 7-8 years old were positively associated with wheezing and asthma and negatively associated with PC20 at ages up to 11-12 years.

Study Type : Human Study

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.