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Article Publish Status: FREE
Abstract Title:

Indole-3-carbinol: a plant hormone combatting cancer.

Abstract Source:

F1000Res. 2018 ;7. Epub 2018 Jun 1. PMID: 29904587

Abstract Author(s):

Ella Katz, Sophia Nisani, Daniel A Chamovitz

Article Affiliation:

Ella Katz

Abstract:

A diet rich in cruciferous vegetables such as cauliflower, broccoli, and cabbage has long been considered healthy, and various epidemiological studies suggest that the consumption of cruciferous vegetables contributes to a cancer-protecting diet. While these vegetables contain a vast array of phytochemicals, the mechanism by which these vegetables counteract cancer is still largely unresolved. Numerousstudies have implicated indole-3-carbinol, a breakdown product of the glucosinolate indole-3-ylmethylglucosinolate, as one of the phytochemicals with anti-cancer properties. Indole-3-carbinol influences a range of cellular processes, but the mechanisms by which it acts on cancer cells are slowly being revealed. Recent studies on the role of indole-3-carbinol in Arabidopsis opens the door for cross-kingdom comparisons that can help in understanding the roles of this important phytohormone in both plant biology and combatting cancer.

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Sayer Ji
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