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Article Publish Status: FREE
Abstract Title:

Induction of substantial myocardial regeneration by an active fraction of the Chinese herb Rosa laevigata Michx.

Abstract Source:

BMC Complement Altern Med. 2015 Oct 14 ;15:359. Epub 2015 Oct 14. PMID: 26467087

Abstract Author(s):

Huiyan Qu, Zhou Feng, Zhongyu Li, Censing Li, Mingfeng Tang, Zhen Zhou, Dianbin Li, Yongming Liu, Ming Li, Hua Zhou

Article Affiliation:

Huiyan Qu

Abstract:

BACKGROUND: The replacement of lost cardiac tissues by regenerated myocardium would be a therapeutic ideal for myocardial infarction. The objective of this study was therefore to evaluate the ability of an active fraction that was isolated from Rosa laevigata Michx in therapeutic cardiomyogenesis in a myocardial infarction rat model.

METHODS: The myocardial infarction animal model was induced by the permanent ligation of the left anterior descending coronary artery in rats. The active fraction, which improves the survival rate and prevents ischemic reperfusion damage, was used to test the therapeutic effect of this fraction on myocardial infarction.

RESULTS: The oral administration of the active fraction for 4 weeks could progressively restore the decreased cardiac function due to myocardial infarction. The significantly improved cardiac function was probably attributed to the active fraction-induced myocardial regeneration, which replaced the lost cardiac tissues in the myocardial infarction animals.

CONCLUSIONS: The property of this active fraction appears to be entirely novel and may provide a potential therapeutic alternative for myocardial infarction.

Study Type : Animal Study

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Sayer Ji
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