Influenza vaccination can induce a systemic immune response. - GreenMedInfo Summary
Systemic Immune Response to Vaccination on FDG-PET/CT.
Nucl Med Mol Imaging. 2016 Dec ;50(4):358-361. Epub 2015 Dec 9. PMID: 27994693
A patient with newly diagnosed right lung cancer had transientF-fluorodeoxyglucose (FDG)-avid left axillary lymph nodes and intense splenic FDG uptake on positron emission tomography (PET)/computed tomography (CT). History revealed that the patient received a left-sided influenza vaccine 2-3 days before the examination. Although inflammatory FDG uptake in ipsilateral axillary nodes is reported, to our knowledge, this is the first report of visualization of the systemic immune response in the spleen related to the influenza vaccination on FDG-PET/CT. The history, splenic uptake and time course on serial FDG-PET/CT helped to avoid a false-positive interpretation for progressing lung cancer and alteration of the radiation therapy plan.