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Article Publish Status: FREE
Abstract Title:

Inhibition ofα-glucosidases by tea polyphenols in rat intestinal extract and Caco-2 cells grown on Transwell.

Abstract Source:

Food Chem. 2021 Nov 1 ;361:130047. Epub 2021 May 11. PMID: 34029903

Abstract Author(s):

Lijiao Kan, Edoardo Capuano, Vincenzo Fogliano, Ruud Verkerk, Jurriaan J Mes, Monic M M Tomassen, Teresa Oliviero

Article Affiliation:

Lijiao Kan

Abstract:

Inhibition of maltase, sucrase, isomaltase and glucoamylase activity by acarbose, epigallocatechin gallate, epicatechin gallate and four polyphenol-rich tea extract from white, green, oolong, black tea, were investigated by using rat intestinal enzymes and human Caco-2 cells. Regarding rat intestinal enzyme mixture, all four tea extracts were very effective in inhibiting maltase and glucoamylase activity, but only white tea extract inhibited sucrase and isomaltase activity and the inhibition was limited. Mixed-type inhibition on rat maltase activity was observed. Tea extracts in combination with acarbose, produced a synergistic inhibitory effect on rat maltase activity. Caco-2 cells experiments were conducted in Transwells. Green tea extract and epigallocatechin gallate show dose-dependent inhibition on human sucrase activity, but no inhibition on rat sucrase activity. The opposite was observed on maltase activity. The results highlighted the different response in the two investigated model systems and show that tea polyphenols are good inhibitors forα-glucosidase activity.

Study Type : Animal Study

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