Abstract Title:

Inhibition of LPS-induced pulmonary inflammation by specific flavonoids.

Abstract Source:

Biochem Biophys Res Commun. 2009 May 8 ;382(3):598-603. Epub 2009 Mar 16. PMID: 19292976

Abstract Author(s):

Liesbeth Geraets, Astrid Haegens, Karen Brauers, Jane A Haydock, Juanita H J Vernooy, Emiel F M Wouters, Aalt Bast, Geja J Hageman

Article Affiliation:

Liesbeth Geraets


In the present study, the anti-inflammatory effects of the flavonoids flavone, fisetin and tricetin were evaluated in a mouse model of LPS-induced acute pulmonary inflammation. The flavonoid fisetin significantly reduced lung myeloperoxidase-levels and gene-expression of inflammatory mediators such as IL-6, TNF-alpha, IL-1beta, MIP-1alpha and MIP-2. The LPS-induced gene transcription of HO-1 and SOD2 was also significantly reduced by fisetin. Overall, the anti-inflammatory effects of fisetin in this in vivo model were much more pronounced as compared to the observed effects of flavone or tricetin and the anti-inflammatory glucocorticoid dexamethasone. The results of this study indicate that flavonoids such as fisetin might be potential candidates as pharmaceuticals or nutraceuticals in the treatment of pulmonary inflammatory diseases.

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