Abstract Title:

Inhibition of platelet aggregation and immunomodulation of NK lymphocytes by administration of ascorbic acid.

Abstract Source:

Indian J Exp Biol. 2011 Dec ;49(12):904-8. PMID: 22403863

Abstract Author(s):

Ioannis K Toliopoulos, Yannis V Simos, Telemachos A Daskalou, Ioannis I Verginadis, Angelos M Evangelou, Spyros C Karkabounas

Article Affiliation:

Ioannis K Toliopoulos


Platelets aggregation around migrating tumor cells offers protection against the cytotoxic activity of the natural killers cells (NKC). The ascorbic acid in 3 x 10(-3) M concentration completely inhibited platelet aggregation, decreased thromboxane B2 levels, and inhibited the expression of platelet membranic receptor GpIIb/IIIa in non stimulated platelets, and increased the NKC cytotoxicity in an average rate of 105, 61, and 285% in the NKC/targets cells ratios 12.5:1, 25:1 and 50:1 respectively. The results suggest the role of ascorbic acid in increasing the susceptibility of tumor cells to NKC; the ascorbic acid could be used as part of a multidrug therapy to treat diseases which up to now have been treated only through chemotherapy.

Study Type : In Vitro Study

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