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Abstract Title:

Caffeic Acid Derivatives from Bacopa monniera Plants as Inhibitors of Pancreatic Lipase Activity and their Structural Requirements.

Abstract Source:

Nat Prod Commun. 2016 Dec ;11(12):1855-1858. PMID: 30508350

Abstract Author(s):

Souichi Nakashima, Tomoe Ohta, Seikou Nakamura, Yoshimi Oda, Mari Koumoto, Eri Kashiwazaki, Maiko Kado, Atsumi Shimada, Ryogo Akita, Hisashi Matsuda

Article Affiliation:

Souichi Nakashima

Abstract:

The methanol extract of whole Bacopa monniera plants inhibited pancreatic lipase activity in vitro. From this extract we have reported the isolation of 11 triterpene glycosides and 5 phenylethanoid- and/or phenylpropanoid- glycosides. In this paper, we describe the effects of the methanol extract and/or its constituents on pancreatic lipase activity and the isolation of an active constituent, desrhamnosyl isoacteoside. In addition, the structural requirements for its inhibitory effects were examined. We also examined the effects on the elevation of plasma triglyceride (TG) levels in olive oil loaded mice. The major active constituents, desrhamnosyl isoacteoside and plantainoside B, reduced plasma TG levels in the mice. The inhibitory effects of B. monniera and its constituents on pancreatic lipase activity and plasma TG level are reported for the first time.

Study Type : Animal Study, In Vitro Study

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