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Abstract Title:

Inhibitory effects of bisdemethoxycurcumin on mast cell-mediated allergic diseases.

Abstract Source:

Int Immunopharmacol. 2018 Dec ;65:182-189. Epub 2018 Oct 10. PMID: 30316076

Abstract Author(s):

Meng Fu, Shuilian Fu, Saihong Ni, Danni Wang, Tie Hong

Article Affiliation:

Meng Fu

Abstract:

Most allergic reactions are induced by mast cell activation. Mast cells play vital roles in the pathogenesis of allergic diseases. Bisdemethoxycurcumin (BDMC), a natural curcuminoid, has potential anti-allergic effects. Hence, we explored the effect of BDMC on mast cell-mediated allergic diseases. The study proved that BDMC suppressesβ-hexosaminidase release, granule release, and membrane ruffling in monoclonal anti-2,4,6-dinitrophenyl-immunoglobulin (Ig) E/human serum albumin (DNP-IgE/HSA)-stimulated rat basophilic leukaemia cells (RBL-2H3 cells), and BDMC suppressed ovalbumin (OVA)-induced allergic rhinitis (AR) symptoms andOVA-specific IgE levels in AR mice. Furthermore, BDMC increased the survival of compound 48/80 anaphylaxis shock mice and elevated the decreased rectal temperature in OVA-induced active systemic anaphylaxis mice. These findings indicate that BDMC regulates the degranulation of mast cells, demonstrating its potential in the treatment of mast cell-induced allergic reactions.

Study Type : In Vitro Study

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