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Article Publish Status: FREE
Abstract Title:

Inhibitory Effects ofβ-Caryophyllene onInfection In Vitro and In Vivo.

Abstract Source:

Int J Mol Sci. 2020 Feb 3 ;21(3). Epub 2020 Feb 3. PMID: 32028744

Abstract Author(s):

Hyun Jun Woo, Ji Yeong Yang, Min Ho Lee, Hyun Woo Kim, Hye Jin Kwon, Min Park, Sung-Kyu Kim, So-Young Park, Sa-Hyun Kim, Jong-Bae Kim

Article Affiliation:

Hyun Jun Woo

Abstract:

The human specific bacterial pathogen() is associated with severe gastric diseases, including gastric cancer. Recently, the increasing resistance makes the usage of antibiotics less effectively. Therefore, development of a new antimicrobial agent is required to controlinfection. In the current study, the inhibitory effect ofβ-caryophyllene ongrowth, as well as the antibacterial therapeutic effect, has been demonstrated.β-caryophyllene inhibitedgrowth via the downregulation ofE,N,B, andA and also downregulated virulence factors such as CagA, VacA, and SecA proteins.β-caryophyllene inhibited expression of several T4SS components, so that CagA translocation into-infected AGS gastric cancer cells was decreased byβ-caryophyllene treatment. β-caryophyllene also inhibited VacA entry through the downregulation of T5SS. Afterβ-caryophyllene administration on Mongolian gerbils, the immunohistochemistry (IHC) and Hematoxylin&Eosin stains showed therapeutic effects in the treated groups. Hematological data, which was consistent with histological data, support the therapeutic effect ofβ-caryophyllene administration. Such a positive effect of β-caryophyllene oninfection potently substantiates the natural compound as being capable of being used as a new antimicrobial agent or functional health food to help patients who are suffering from gastroduodenal diseases due toinfection.

Study Type : Animal Study, In Vitro Study

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