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Abstract Title:

Inhibitory potential of Hydroxychavicol on Ehrlich ascites carcinoma model andinteraction on cancer targets.

Abstract Source:

Nat Prod Res. 2020 Jun ;34(11):1591-1596. Epub 2018 Nov 23. PMID: 30470141

Abstract Author(s):

Vedagiri Hemamalini, Dass Prakash M Velayutham, Loganathan Lakshmanan, Karthikeyan Muthusamy, Sivaperumal Sivaramakrishnan, Kumpati Premkumar

Article Affiliation:

Vedagiri Hemamalini

Abstract:

Hydroxychavicol (HC), a major phenolic derivative isolated from the leaves ofis well known for its antibacterial, antifungal and antimutagenic properties. The present study evaluated theantitumor activity of HC against Ehrlich Ascites Carcinoma (EAC) cells in Swiss albino mice andinteraction of HC with the receptors involved in the cancer. Hydroxychavicol (200 and 400 mg/kg bw) was orally administered for 21 consecutive days and was effective in inhibiting the tumor growth in ascitic mouse model. HC consistently reduced the tumor volume, viable cell count, lipid peroxidation and elevated the life span of HC treated mice. Besides the hematological profiles, SGOT and SGPT levels reverted back to normal and oxidative stress markers GSH, SOD and CAT also increased in HC treated groups.docking analysis revealed that HC possessed potent antagonist activity against all the cancer targets demonstrating its inhibitory activity.

Study Type : Animal Study

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