Abstract Title:

Inositol hexaphosphate inhibits growth and induces differentiation of PC-3 human prostate cancer cells.

Abstract Source:

Carcinogenesis. 1995 Aug;16(8):1975-9. PMID: 7634429

Abstract Author(s):

A M Shamsuddin, G Y Yang

Article Affiliation:

Department of Pathology, University of Maryland School of Medicine, Baltimore 21201, USA.

Abstract:

We investigated the effects of inositol hexaphosphate (InsP6) on growth inhibition and differentiation of human prostate cancer cells PC-3 in vitro. A significant dose- and time-dependent growth inhibition was observed as tested by the MTT-incorporation assay (P<0.05 at 1 mM InsP6 after 24 h treatment, P<0.01 at 0.1 mM after 3 days). DNA synthesis as determined by [3H]thymidine incorporation assay was also suppressed by InsP6 in a dose-dependent manner, occurring as early as 3 h after treatment and continuing up to 48 h (P<0.01 at 1 mM InsP6). A 9- to 10-fold increase (P<0.01) in expression of HLA class I molecule associated with tumor immunosurveillance and cell differentiation was induced by InsP6. The marker for prostatic cell differentiation, prostate acid phosphatase, was significantly (P<0.05) increased after 48 h treatment at 0.5-5 mM InsP6. Since InsP6 strongly inhibits growth and induces differentiation in human prostate cancer cells in vitro, in vivo studies using a tumor xenograft model and a prostate carcinogenesis model are warranted to validate the efficacy of InsP6 in the treatment and prevention of prostate cancer.

Study Type : In Vitro Study

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