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Article Publish Status: FREE
Abstract Title:

Intestinal Microbiota Influences Non-intestinal Related Autoimmune Diseases.

Abstract Source:

Front Microbiol. 2018 ;9:432. Epub 2018 Mar 12. PMID: 29593681

Abstract Author(s):

Maria C Opazo, Elizabeth M Ortega-Rocha, Irenice Coronado-Arrázola, Laura C Bonifaz, Helene Boudin, Michel Neunlist, Susan M Bueno, Alexis M Kalergis, Claudia A Riedel

Article Affiliation:

Maria C Opazo

Abstract:

The human body is colonized by millions of microorganisms named microbiota that interact with our tissues in a cooperative and non-pathogenic manner. These microorganisms are present in the skin, gut, nasal, oral cavities, and genital tract. In fact, it has been described that the microbiota contributes to balancing the immune system to maintain host homeostasis. The gut is a vital organ where microbiota can influence and determine the function of cells of the immune system and contributes to preserve the wellbeing of the individual. Several articles have emphasized the connection between intestinal autoimmune diseases, such as Crohn's disease with dysbiosis or an imbalance in the microbiota composition in the gut. However, little is known about the role of the microbiota in autoimmune pathologies affecting other tissues than the intestine. This article focuses on what is known about the role that gut microbiota can play in the pathogenesis of non-intestinal autoimmune diseases, such as Grave's diseases, multiple sclerosis, type-1 diabetes, systemic lupus erythematosus, psoriasis, schizophrenia, and autism spectrum disorders. Furthermore, we discuss as to how metabolites derived from bacteria could be used as potential therapies for non-intestinal autoimmune diseases.

Study Type : Review

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