Abstract Title:

Prevention of hormonal breast cancer by dietary jamun.

Abstract Source:

Mol Nutr Food Res. 2016 Mar 31. Epub 2016 Mar 31. PMID: 27030099

Abstract Author(s):

Farrukh Aqil, Jeyaprakash Jeyabalan, Radha Munagala, Inder Pal Singh, Ramesh C Gupta

Article Affiliation:

Farrukh Aqil

Abstract:

SCOPE: Syzygium cumini (Jamun) is perhaps the only berry that has the diversity of anthocyanidins of blueberry and bilberry and the abundance of ellagitannins/ellagic acid of black raspberry. Here we report the potential of jamun against 17β-estrogen-mediated breast cancer and the role of miRNAs and other targets in disease inhibition.

METHODS AND RESULTS: Female ACI rats were given AIN-93M diet or diet supplemented with jamun. Two weeks later, animals received 17β-estradiol and were palpated weekly for the mammary tumors. At the end of 26 week, the jamun-diet significantly delayed the first tumor appearance by 21 days, and reduced the tumor incidence (65% vs 96%), tumor burden (313±95 vs 661±123 mm(3) ) and tumor multiplicity (1.8±0.3 vs 4.2±0.4 tumors/rat) compared to control. The experimental diet significantly reduced the estrogen-associated growth of pituitary prolactinomas, circulating prolactin and estradiol levels and offset estrogen-associated increases in mammary cell-proliferation, ER-α and cyclinD1. MiRNAs that were either overexpressed (miR-182 and miR-375) or underexpressed (miR-127 and miR-206) following estrogen-treatment were significantly protected by jamun diet.

CONCLUSIONS: Together, our data show that jamun significantly offset estrogen-mediated alterations in mammary cell-proliferation, ER-α, cyclinD1, and candidate miRNAs, and that the modulation of these biomarkers correlated with a reduction in mammary carcinogenicity. This article is protected by copyright. All rights reserved.

Print Options


This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.