Article Publish Status: FREE
Abstract Title:

Open Randomized Clinical Trial on JWSJZ Decoction for the Treatment of ALS Patients.

Abstract Source:

Evid Based Complement Alternat Med. 2013 ;2013:347525. Epub 2013 Sep 5. PMID: 24093046

Abstract Author(s):

Weidong Pan, Xiaojing Su, Jie Bao, Jun Wang, Jin Zhu, Dingfang Cai, Li Yu, Hua Zhou

Article Affiliation:

Weidong Pan


Objective. To investigate the efficacy and safety of the traditional Chinese medicine Jiawei Sijunzi (JWSJZ) decoction for the treatment of patients with amyotrophic lateral sclerosis (ALS). Methods. Forty-eight patients with ALS were divided into a JWSJZ group (n = 24) and a control group (n = 24) using a randomized number method. Together with the basic treatment for ALS, JWSJZ decoction was added to the treatment regimen of patients in the JWSJZ group or Riluzole was administered to the control group for 6 months. Neurologists evaluated the treated and control patients using the ALS functional rating scale (ALSFRS) before, 3 and 6 months after starting the additional treatments. Results. The ALSFRS scores in both groups were lower 3 and 6 months after treatment than before. There was a significant difference at 6 months after treatment between the subgroups of patients with ALS whose limbs were the initial site of attack. No serious adverse effects were observed in the JWSJZ group. Conclusion. JWSJZ decoction may be a safe treatment for ALS, and may have delayed the development of ALS, especially in the subgroup of patients in whom the limbs were attacked first when compared with Riluzole treatment.

Study Type : Human Study

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