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Abstract Title:

Kaempferol protects against gamma radiation-induced mortality and damage via inhibiting oxidative stress and modulating apoptotic molecules in vivo and vitro.

Abstract Source:

Environ Toxicol Pharmacol. 2018 Apr 20 ;60:128-137. Epub 2018 Apr 20. PMID: 29705372

Abstract Author(s):

Jing Wang, Tiejun Li, Jingjing Feng, Li Li, Rong Wang, Hao Cheng, Yongfang Yuan

Article Affiliation:

Jing Wang

Abstract:

To investigate the potential protective effect of kaempferol, a representative flavonoid, against radiation induced mortality and injury in vivo and vitro.C57BL/6 male mice and human umbilical venous endothelial cells (HUVECs) were pretreated with kaempferol before radiation. We found that kaempferol can effectively increase 30-day survival rate after 8.5 Gy lethal total body irradiation (TBI). Mice were sacrificed at 7th day after 7 Gy TBI, we found kaempferol against radiation-induced tissues damage, by inhibiting the oxidative stress, and attenuating morphological changes and cell apoptosis. In vitro, kaempferol increased HUVECs cell viability and decrease apoptosis. It also mitigated oxidative stress and restored the abnormal expression of prx-5, Cyt-c, Caspase9 and Caspase3 in mRNA and protein level in HUVECs after radiation. Taken together, it suggests kaempferol can protect against gamma-radiation induced tissue damage and mortality. The present study is the first report of the radioprotective role of kaempferol in vivo and vitro.

Study Type : Animal Study, In Vitro Study
Additional Links
Diseases : Radiation
Pharmacological Actions : Radioprotective : CK(1247) : AC(406)

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