Key lime inhibits the growth of triple drug resistant Helicobacter pylori. - GreenMedInfo Summary
Key lime () inhibits the growth of triple drug resistant.
Gut Pathog. 2018 ;10:16. Epub 2018 May 21. PMID: 29942354
Background: Eradication rate for() has decreased due to antibiotic resistance. Therefore, new strategies are needed to enhanceeradication, especially forwith high antibiotic resistance. The objective of this study was to evaluate anti-activities of constituents from key lime () and their possible inhibitory effects on urease activity of
Methods: strain ATCC 43526 and triple drug resistant (TDR)strains were used in this study. Urease activities ofstrains were measured by ammonia colorimetrical quantification using ELISA reader. Minimum inhibitory concentrations were determined by agar dilution method for antibiotics and by modified media dilution method for each constituent of().
Results: extract decreased the number of colonies ofstrain ATCC 43526 and TDR. An increasing concentration ofextract attenuated urease activities ofstrain ATCC 43526 and TDRstrains. Among constituents of, citral and 4-hexen-3-one were found to be able to inhibit the growth ofstrain ATCC 43526 and TDRstrains. Furthermore, citral and 4-hexen-3-one inhibited urease activities ofstrain ATCC 43526 and TDRstrains in a dose-dependent manner.
Conclusion: has antimicrobial effect on TDRstrains, suggesting thatmight have therapeutic potential to control antibiotic-resistantstrains that cause eradication failure using other antibiotics.