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Abstract Title:

Kidney-targeted Astaxanthin Natural Antioxidant Nanosystem for Diabetic Nephropathy Therapy.

Abstract Source:

Eur J Pharm Biopharm. 2020 Sep 13. Epub 2020 Sep 13. PMID: 32937179

Abstract Author(s):

Zhong Chen, Wenhua Li, Liwang Shi, Lei Jiang, Minghui Li, Changmei Zhang, Haisheng Peng

Article Affiliation:

Zhong Chen

Abstract:

Diabetic nephropathy (DN) is a frequent and severe microvascular complication associated with oxidative stress of diabetes mellitus. A novel astaxanthin-based natural antioxidant nanosystem, namely AST-GLU-LIP, with preferential renal uptake and bioavailability were prepared and applied for treatment of diabetic nephropathy in rats. Our results of kidney-targeted evaluation showed that glucose-PEG-DSPE ligand modified AST liposomes could be specifically transported by overexpressed GLUT1 on the membrane of glomerular mesangial cells and achieved excellent kidney-targeted drug delivery. In addition, the results of pharmacodynamics and therapeutics in DN rats demonstrated that AST-GLU-LIP could improve the bioavailability and antioxidant capacity of AST to scavenge redundant ROS induced by oxidative stress. AST-GLU-LIP could also significantly improve the renal pathological morphology to protect the kidney as a therapeutic drug for diabetic nephropathy.

Study Type : Animal Study

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Sayer Ji
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