Article Publish Status: FREE
Abstract Title:

Korean Red Ginseng Extract Increases Apoptosis by Activation of the Noxa Pathway in Colorectal Cancer.

Abstract Source:

Nutrients. 2019 Aug 29 ;11(9). Epub 2019 Aug 29. PMID: 31470581

Abstract Author(s):

Yoon A Jeong, Bo Ram Kim, Dae Young Kim, Soyeon Jeong, Yoo Jin Na, Jung Lim Kim, Hye Kyeong Yun, Bu Gyeom Kim, Seong Hye Park, Min Jee Jo, Sun Il Lee, Byung-Cheol Han, Dae-Hee Lee, Sang Cheul Oh

Article Affiliation:

Yoon A Jeong


BACKGROUND: Although the anticancer activity of Korean Red Ginseng (KRG) has been known in various cancers, the mechanism of KRG-induced apoptosis is unknown in colorectal cancer (CRC). In our study, we examined whether KRG induces apoptosis in CRC cells.

METHODS: In the cell viability assay, the concentration of the appropriate KRG extracts was fixed at 2.5 mg/mL in numerous CRC cells. This fixed concentration was in other experiments, and it was confirmed that the KRG extracts induce apoptosis in CRC cells.

RESULTS: We found that KRG induced Noxa activation and apoptosis and increased endoplasmic reticulum stress via reactive oxygen species production. This indicated that KRG efficiently enhanced cell death in CRC cells.

CONCLUSION: Our results show that KRG can be used as a possible anticancer drug for patients with CRC.

Study Type : In Vitro Study

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Sayer Ji
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