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Article Publish Status: FREE
Abstract Title:

Korean Thistle (var.(Maxim.) Matsum.): A Potential Dietary Supplement against Diabetes and Alzheimer's Disease.

Abstract Source:

Molecules. 2019 Feb 12 ;24(3). Epub 2019 Feb 12. PMID: 30759846

Abstract Author(s):

Aditi Wagle, Su Hui Seong, Srijan Shrestha, Hyun Ah Jung, Jae Sue Choi

Article Affiliation:

Aditi Wagle

Abstract:

In the search for natural products having a dual inhibitory action on diabetes and Alzheimer's disease, this study investigated the activity of different parts of Korean thistle (var.(Maxim.) Matsum), and its fractional constituents by in vitro enzymatic and in silico molecular docking studies.has been used as a traditional medicine for the treatment of several diseases. The ethyl acetate and dichloromethane fractions of a leaf extract showedα-glucosidase and BACE1 inhibitory activity, respectively. Furthermore, the isolated compound, luteolin, exhibited concentration-dependent non-competitive inhibition against both α-glucosidase and BACE1 (IC= 51.27± 1.23 and 13.75 ± 0.26 μM;value = 52.04 and 14.76μM, respectively). Moreover, docking studies showed that luteolin formed a strong hydrogen bond with the peripheral binding amino acid residues, and hydrophobic interactions with the α-glucosidase and BACE1 enzymes. Therefore, Korean thistle may act as an important dietary supplement against diabetes and Alzheimer's disease, especially the leaves, because of the preponderance of the active component, luteolin, making Korean thistle a promising candidate for more detailed in vitro and in vivo studies.

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