Abstract Title:

L-5-hydroxytryptophan attenuates positive psychotic symptoms induced by D-amphetamine.

Abstract Source:

Mol Cells. 2009 Feb;27(2):191-8. Epub 2009 Feb 20. PMID: 3501597

Abstract Author(s):

M R Irwin, S R Marder, F Fuentenebro, A Yuwiler

Article Affiliation:

Veterans Administration Medical Center, Clinical Research Center on Alcoholism, San Diego, CA 92161.


Brain serotonin has been hypothesized to be involved in the modulation of psychotic symptoms in at least some forms of schizophrenia. We examined the effects of the serotonin precursor L-5-hydroxytryptophan (5HTP) on D-amphetamine induction of acute psychotic symptoms in schizophrenic patients. Preadministration with 5HTP significantly antagonized amphetamine-elicited elevations in thought disturbance, activation, and hallucinations.

Study Type : Commentary

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