Abstract Title:

L-5-hydroxytryptophan attenuates positive psychotic symptoms induced by D-amphetamine.

Abstract Source:

Mol Cells. 2009 Feb;27(2):191-8. Epub 2009 Feb 20. PMID: 3501597

Abstract Author(s):

M R Irwin, S R Marder, F Fuentenebro, A Yuwiler

Article Affiliation:

Veterans Administration Medical Center, Clinical Research Center on Alcoholism, San Diego, CA 92161.

Abstract:

Brain serotonin has been hypothesized to be involved in the modulation of psychotic symptoms in at least some forms of schizophrenia. We examined the effects of the serotonin precursor L-5-hydroxytryptophan (5HTP) on D-amphetamine induction of acute psychotic symptoms in schizophrenic patients. Preadministration with 5HTP significantly antagonized amphetamine-elicited elevations in thought disturbance, activation, and hallucinations.

Study Type : Commentary

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