L-5-hydroxytryptophan attenuates positive psychotic symptoms induced by D-amphetamine. - GreenMedInfo Summary
L-5-hydroxytryptophan attenuates positive psychotic symptoms induced by D-amphetamine.
Mol Cells. 2009 Feb;27(2):191-8. Epub 2009 Feb 20. PMID: 3501597
Veterans Administration Medical Center, Clinical Research Center on Alcoholism, San Diego, CA 92161.
Brain serotonin has been hypothesized to be involved in the modulation of psychotic symptoms in at least some forms of schizophrenia. We examined the effects of the serotonin precursor L-5-hydroxytryptophan (5HTP) on D-amphetamine induction of acute psychotic symptoms in schizophrenic patients. Preadministration with 5HTP significantly antagonized amphetamine-elicited elevations in thought disturbance, activation, and hallucinations.