L. sakei S1 may inhibit the NF-κB pathway and be used as functional food to treat colitis. - GreenMedInfo Summary

S1 strongly inhibits the expression of interleukin (IL)-6 and IL-1β in lipopolysaccharide-induced peritoneal macrophages for the mechanism that lactic acid bacteria from kimchi inhibit tumor necrosis factor-alpha (TNF-α) was isolated. The protective effect of this strain on the colitis mouse model induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS) was furtherevaluated. TNBS significantly elevated myeloperoxidase (MPO) expression, macroscopic scores, and colon shortening. OralS1 administration resulted in reduction of TNBS-induced loss in body weight, colon shortening, MPO activity, expression of cyclooxygenase (COX)-2, inducible nitric oxide synthase (iNOS) and nuclear factor-kappa B (NF-κB).S1 inhibited the expression of inflammatory cytokines IL-1β, IL-6 and TNF-α, induced by TNBS, but enhanced IL-10 expression.S1 showed resistance to artificial digestive juices and adherence to intestinal epithelial Caco-2 cells. Thus,S1 may inhibit the NF-κB pathway and be used as functional food to treat colitis.