Article Publish Status: FREE
Abstract Title:

L-theanine and Neumentix mixture improves sleep quality and modulates brain neurotransmitter levels in mice.

Abstract Source:

Ann Palliat Med. 2021 Apr ;10(4):4572-4581. PMID: 33966405

Abstract Author(s):

Ying Zhang, Xiuzhen Jia, Ximin Chen, Yajuan Liu, Zifu Zhao, Jingyu Hao, Rui Wu, Haotian Feng, Xiangnan Ren

Article Affiliation:

Ying Zhang


BACKGROUND: L-theanine (L-THE), a natural amino acid found in green tea, has been shown to improve anxiety and sleep. Neumentix proprietary spearmint extract (PSE), which is commonly found in beverage flavoring a pharmaceutical, also has a wide range of health benefits, including cognitive performance improvement.

METHODS: Four experiments tested the effects of L-THE and PSE on sleep: a direct sleeping test, pentobarbital-induced sleeping test, sub-hypnotic pentobarbital-induced sleeping test, and sodium barbital-induced sleeping test. Presence of neurotransmitters in brain tissue was detected by liquid chromatography mass spectroscopy (HP LC-MS) during these studies.

RESULTS: Pentobarbital-induced sleeping and sodium barbital-induced sleeping tests examined the potential effect of L-THE/PSE mixture on synergistic sleep, while neurotransmitter levels in the brain were determined by the high performance liquid chromatography/mass spectroscopy (HPLC/MS) method. L-THE and L-THE/PSE mixture showed increased sleep duration and shortened sleep latency when co-administrated with pentobarbital or sodium barbital. The mixture also increased sleeping rate when co-administrated with the pentobarbital at sub-hypnotic dose. Additionally, the L-THE, PSE and L-THE/PSE mixture significantly increased the concentrations of acetylcholine (Ach),γ-aminobutyric acid (GABA), and decreased the concentration of serotonin (5-HT) in the brain.

CONCLUSIONS: These data demonstrated that L-THE/PSE mixture regulates sleep disorders via the GABA receptor and neurotransmitter systems.

Study Type : Animal Study

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Sayer Ji
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